Fig. 8

Model for the role of Rab4b in the GARP-dependent retrograde trafficking pathway. The proposed possible model is based on results from this article and previous publications cited in the text. A In the absence of Rab4b, CI-M6PR and of the TfR are segregated and their trafficking route to the TGN and the recycling endosomes, respectively, is inhibited. The Rab4b effectors AP-1 and VPS52 remain on the endosomes. B In the absence of VPS52 and VPS54, CI-M6PR and of the TfR are not segregated, and they are targeted in a Rab4b/AP-1-dependent